Five different river cruise ships operated by American Cruise Lines sail the Mississippi River offering 12+ itineraries all year-round.
There can be no better way to sail the Mighty Mississippi and its tributaries. The company’s Mississippi five ship offerings, range from 8 to 51 days. They include an array of authentic experiences in 10 states from New Orleans in Louisiana to St. Paul in Minnesota.
American Cruise Lines’ Mississippi season officially opens on February 21st aboard the award-winning American Serenade. She sails a classic 9-Day Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN.
Of the five new itineraries for 2025, one is the brand new 12-Day Mississippi Explorer Cruise. It runs from Memphis to New Orleans.
Other ships in in the five strong fleet offer several exclusive itineraries on the Tennessee, Cumberland, and Ohio Rivers. These include a new 16-Day Grand Ohio River Cruise from Pittsburgh to St. Louis.
Explore the Mississippi
Mississippi offerings also showcase two of the longest U.S. River cruises on the market. The first is a new 51-Day Great United States Cruise. A second offers a 36-Day Civil War Battlefields Cruise. These Extended Cruises sail the entire Mississippi or major sections of the River in addition to other U.S. waterways.
American Cruise Lines is the only line offering U.S. River cruises aboard both classic paddlewheelers and five new modern riverboats.
The company’s world-class riverboats are less than half the size of other riverboats. They deliver the most personalised river cruise experiences available along the Nation’s most iconic waterway.
Highlights include visits to Elvis Presley’s Graceland and Mark Twain’s boyhood home. They include off-the-beaten path adventures from Cajun Swamp safaris to ATV treks. Or explorations of classic American landmarks like the St. Louis Arch and Vicksburg National Military Park. Others feature deep cultural dives into music, cuisine, and history.
Five 2025 cruises explore the Mississippi also include holiday and themed cruises, from Mark Twain to Culinary to Civil War and Christmas cruises, and even a National Parks cruise visiting Great Smoky Mountains National Park.
All cruises feature included Pre-Cruise hotel stays. Plus, onboard enrichment and entertainment, shoreside excursions, private transportation. Fine cuisine, Wi-Fi, complimentary cocktails, are also included.
Cruise Fares include Tips and Gratuities and Port Charges and Fees. All cruises also offer guests the opportunity to purchase Flat-Rate Domestic Airfare and select 2025 sailings offer Complimentary Domestic Airfare. Cruises operate in both directions.
Most awarded river cruise line
American Cruise Lines is the country’s most awarded river cruise line. Recent awards include Cruise Critic’s 2024 award for Best for Solo Travelers. It won Travel Weekly’s 2024 Magellan Award for Best Mississippi River Cruises.
American Cruise Lines is the largest river cruise line in the U.S.A. with 21 small ships exploring the Mississippi River and waterways around the country. The company’s award-winning fleet and domestic itineraries build on a 50-year history of delivering curated all-American explorations. Today, the company offers luxury river cruise experiences in 35 states. It operates the only 100% U.S. flagged fleet of riverboats and small ships in the world. All sailing exclusively in the U.S.A.
